A substrate or polyethyleneglycol (PEG) imprinted lipase nanogel displayed increased apparent activity in organic solvents by 2.5–4.7 folds, compared to native lipase. It enabled a one-step synthesis of chloramphenicol palmitate with a yield of ∼99% and purity of ∼99%, indicating that the imprinted lipase nanogel is an appealing catalyst in organic media.
R. Wang, Y. Zhang, J. Ge and Z. Liu, RSC Adv., 2014, 4, 40301 DOI: 10.1039/C4RA06660J
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