Issue 93, 2014

Direct synthesis of α-hydroxyacetophenones through molecular iodine activation of carbon–carbon double bonds

Abstract

An I2-promoted activation of carbon–carbon double bonds has been demonstrated. This simple and efficient domino process was utilized for the direct construction of α-hydroxyacetophenones in moderate to good yields from easily available styrenes at room temperature. This approach involved molecular iodine activation of carbon–carbon double bonds to form an iodonium intermediate. Moreover, TBHP was used as the sole effective oxidant and water was used as nucleophilic reagent in this reaction.

Graphical abstract: Direct synthesis of α-hydroxyacetophenones through molecular iodine activation of carbon–carbon double bonds

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2014
Accepted
07 Oct 2014
First published
07 Oct 2014

RSC Adv., 2014,4, 51180-51183

Direct synthesis of α-hydroxyacetophenones through molecular iodine activation of carbon–carbon double bonds

X. Wu, Q. Gao, M. Lian, S. Liu and A. Wu, RSC Adv., 2014, 4, 51180 DOI: 10.1039/C4RA07012G

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