Toward transmembrane anionophores based on rigid bis(choloyl) conjugates: reversal of the ion selectivity by appended polyamines

Abstract

A bis(choloyl) conjugate tethered with a bis(polyamine)-appending rigid linker was synthesized and found to efficiently promote the exchange of anions across egg-yolk L-α-phosphatidylcholine-based liposomal membranes. This is in sharp contrast to a previous finding that its analog having two monoamino groups acted as a cation/proton antiporter.