Issue 68, 2014
From the journal:

RSC Advances

Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates†

Qi Sun,*a   Jian Sun,a   Shan-Shan Gong,a   Cheng-Jun Wang,a   Shou-Zhi Pua  and  Fu-De Feng*b  

* Corresponding authors

a Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, 605 Fenglin Avenue, Nanchang, Jiangxi 330013, PR China
E-mail: sunqi96@tsinghua.org.cn
Tel: +86 791 83805183

b Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, PR China
E-mail: fengfd@nju.edu.cn
Tel: +86 25 83592119

Abstract

An efficient P(V)-N activation strategy for the preparation of high-quality 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine triphosphates has been developed. The method was also optimized for gram-scale synthesis of the corresponding parent nucleosides from 2′-deoxythymidine.

Graphical abstract: Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates

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Article information

DOI
https://doi.org/10.1039/C4RA07670B
Article type
Communication
Submitted
06 Jun 2014
Accepted
06 Aug 2014
First published
06 Aug 2014

RSC Adv., 2014,4, 36036-36039

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Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates

Q. Sun, J. Sun, S. Gong, C. Wang, S. Pu and F. Feng, RSC Adv., 2014, 4, 36036 DOI: 10.1039/C4RA07670B

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