Issue 92, 2014
From the journal:

RSC Advances

Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques†

Fazli Sozmen,‡a   Safacan Kolemen,‡a   Henri-Obadja Kumada,b   Masahiro Ono,b   Hideo Sajib  and  Engin U. Akkaya*ac  

* Corresponding authors

a UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey
E-mail: eua@fen.bilkent.edu.tr
Fax: +90 312 266 4068
Tel: +90 312 290 3568

b Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan

c Department of Chemistry, Bilkent University, Ankara 06800, Turkey

Abstract

Styryl-congutated BODIPY dyes which are structurally similar to known Aβ peptide binding dyes, were designed and synthesized. The binding is accompanied by a large increase in the emission intensity in all cases, suggesting a high potential for use in the fluorescence imaging of Aβ plaques.

Graphical abstract: Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques

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Article information

DOI
https://doi.org/10.1039/C4RA07754G
Article type
Paper
Submitted
29 Jul 2014
Accepted
04 Sep 2014
First published
04 Sep 2014

RSC Adv., 2014,4, 51032-51037

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Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques

F. Sozmen, S. Kolemen, H. Kumada, M. Ono, H. Saji and E. U. Akkaya, RSC Adv., 2014, 4, 51032 DOI: 10.1039/C4RA07754G

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