Issue 105, 2014
From the journal:

RSC Advances

Advantageous asymmetric ketone reduction with a competitive hydrogenation/transfer hydrogenation system using chiral bifunctional iridium catalysts†

Junki Moritani,a   Yoshihito Kayakia  and  Takao Ikariya*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, O-okayama 2-12-1-E4-1, Meguro-ku, Tokyo 152-8552, Japan
E-mail: tikariya@apc.titech.ac.jp

Abstract

Hydrogenation of aromatic ketones with chiral bifunctional amidoiridium complexes proceeds in preference to transfer hydrogenation in methanol, in which the pressurised hydrogen can suppress unintended racemisation of the alcoholic product, leading to enhanced enantioselectivity.

Graphical abstract: Advantageous asymmetric ketone reduction with a competitive hydrogenation/transfer hydrogenation system using chiral bifunctional iridium catalysts

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Article information

DOI
https://doi.org/10.1039/C4RA07854C
Article type
Communication
Submitted
31 Jul 2014
Accepted
23 Oct 2014
First published
23 Oct 2014

RSC Adv., 2014,4, 61001-61004

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Advantageous asymmetric ketone reduction with a competitive hydrogenation/transfer hydrogenation system using chiral bifunctional iridium catalysts

J. Moritani, Y. Kayaki and T. Ikariya, RSC Adv., 2014, 4, 61001 DOI: 10.1039/C4RA07854C

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