Fabrication of a novel magnetic yolk–shell Fe3O4@mTiO2@mSiO2 nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample

Hao Wan; Jinan Li; Wenguang Yu; Zheyi Liu; Quanqing Zhang; Weibing Zhang; Hanfa Zou

doi:10.1039/C4RA08692A

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Fabrication of a novel magnetic yolk–shell Fe₃O₄@mTiO₂@mSiO₂ nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample†

Hao Wan,^ab Jinan Li,^b Wenguang Yu,^b Zheyi Liu,^b Quanqing Zhang,^b Weibing Zhang*^a and Hanfa Zou*^b

Author affiliations

* Corresponding authors

^a Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China
E-mail: weibingzhang@ecust.edu.cn

^b CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China
E-mail: hanfazou@dicp.ac.cn

Abstract

A yolk–shell nanocomposite composed of a magnetic mesoporous anatase TiO₂ (Fe₃O₄@mTiO₂) core, a medium cavity and an outermost mesoporous silica (mSiO₂) shell was successfully fabricated. Due to a combination of the strong magnetic response, improved diffusion of peptides, numerous affinity sites towards phosphopeptides and the size-exclusion effect, the nanocomposite demonstrated high enrichment efficacy and selectivity towards endogenous phosphopeptides from human serum.

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Article information

DOI: https://doi.org/10.1039/C4RA08692A
Article type: Communication
Submitted: 15 Aug 2014
Accepted: 12 Sep 2014
First published: 12 Sep 2014

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RSC Adv., 2014,4, 45804-45808

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Fabrication of a novel magnetic yolk–shell Fe₃O₄@mTiO₂@mSiO₂ nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample

H. Wan, J. Li, W. Yu, Z. Liu, Q. Zhang, W. Zhang and H. Zou, RSC Adv., 2014, 4, 45804 DOI: 10.1039/C4RA08692A

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