Facile synthesis of 2-substituted quinolines and 3-alkynyl-2-aryl-2H-Indazole via SnCl2-mediated reductive cyclization

Narayanasamy Sudhapriya; Avanashiappan Nandakumar; Paramasivan Thirumalai Perumal

doi:10.1039/C4RA09153A

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Facile synthesis of 2-substituted quinolines and 3-alkynyl-2-aryl-2H-Indazole via SnCl₂-mediated reductive cyclization†

Narayanasamy Sudhapriya,^a Avanashiappan Nandakumar^a and Paramasivan Thirumalai Perumal*^a

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* Corresponding authors

^a Organic Chemistry Division, CSIR-Central Leather Research Institute, Adyar, Chennai-600020, India
E-mail: ptperumal@gmail.com

Abstract

A rapid and efficient SnCl₂·2H₂O mediated synthesis of quinolines and indazoles has been developed using A³-coupling followed by reductive cyclization. The key highlights are the formation of quinoline in a one-pot fashion and indazole through N–N bond formation.

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Article information

DOI: https://doi.org/10.1039/C4RA09153A
Article type: Communication
Submitted: 23 Aug 2014
Accepted: 29 Oct 2014
First published: 29 Oct 2014

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RSC Adv., 2014,4, 58476-58480

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Facile synthesis of 2-substituted quinolines and 3-alkynyl-2-aryl-2H-Indazole via SnCl₂-mediated reductive cyclization

N. Sudhapriya, A. Nandakumar and P. T. Perumal, RSC Adv., 2014, 4, 58476 DOI: 10.1039/C4RA09153A

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