Human serum albumin (HSA) is chosen to investigate the interaction of graphene oxide-based nanosheets (GONS) with plasma proteins in terms of binding affinity, action mechanism, conformational change and function loss. We show that GONS inhibit HSA function via two routes: blocking protein active sites, or destroying protein structure.
Z. Ding, H. Ma and Y. Chen, RSC Adv., 2014, 4, 55290 DOI: 10.1039/C4RA09613D
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