Synthesis of symmetrical and unsymmetrical bis(pyrrolo[2,3-d]pyrimidinyl)methanes

Abstract

Some novel symmetrical bis(pyrrolo[2,3-d]pyrimidinyl)methanes were synthesized via diheteroarylation of sp³ CH bond of acetophenones with molecular iodine and DMSO. Further, an efficient reaction protocol was developed with which both symmetrical and some novel unsymmetrical bis(pyrrolo[2,3-d]pyrimidinyl)methanes were synthesized. For this purpose, we have exploited the highly reactive and good leaving nature of 1,3-dimethylbarbituric acid.