Issue 99, 2014
From the journal:

RSC Advances

A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging†

Jun Yuan,‡a   Yu-Qiong Xu,‡a   Nan-Nan Zhou,b   Rui Wang,b   Xu-Hong Qiana  and  Yu-Fang Xu*a  

* Corresponding authors

a Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: yfxu@ecust.edu.cn

b Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Abstract

Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull–push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

Graphical abstract: A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

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Article information

DOI
https://doi.org/10.1039/C4RA10044A
Article type
Communication
Submitted
09 Sep 2014
Accepted
22 Oct 2014
First published
24 Oct 2014

RSC Adv., 2014,4, 56207-56210

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A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

J. Yuan, Y. Xu, N. Zhou, R. Wang, X. Qian and Y. Xu, RSC Adv., 2014, 4, 56207 DOI: 10.1039/C4RA10044A

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