Portable resistive pulse-activated lens-free cell imaging system

Abstract

We demonstrate a portable lens-free cell imaging system activated by resistive pulses that are induced by biological cells in a microfluidic channel. This imaging on-chip flow cytometer integrates CMOS with microfluidics as a standalone on-chip analytical device. The preliminary version of this system is able to provide dual-parametric study (light contrast image and modulated electrical pulse) for each biological cell. Red blood cells and a tumor cell line (HepG2) are used to demonstrate the performance of this chip for flow analysis of biological samples.