A novel assembling complex of hydrobobic phthalocyanine-cyclodextrin: preparation, characterization, molecular modeling, and in vitro activity

S. Lu; Y. J. Ma; H. Y. Xuan; A. Wang; B. Zhao; X. D. Li; J. H. Zhou; Y. Lin; L. Zhou; S. H. Wei

doi:10.1039/C4RA12654H

A novel assembling complex of hydrobobic phthalocyanine-cyclodextrin: preparation, characterization, molecular modeling, and in vitro activity†

S. Lu,^a Y. J. Ma,^a H. Y. Xuan,^a A. Wang,^a B. Zhao,^a X. D. Li,^a J. H. Zhou,^a Y. Lin,^a L. Zhou*^a and S. H. Wei*^a

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* Corresponding authors

^a College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Wenyuan Road No. 1, Nanjing, China
E-mail: zhoulin@njnu.edu.cn, shwei@njnu.edu.cn
Fax: +86-25-85891761
Tel: +86-25-85891761

Abstract

The stable 4 : 1 host–guest complex of phthalocyanine (Pc) and hydroxypropyl-beta-cyclodextrin was designed, computer modeled and prepared. The complex formation can greatly increase water solubility, reactive oxygen generation ability, biocompatibility and, thereby, the in vitro phototoxicity of Pc to cancer cells.

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A novel assembling complex of hydrobobic phthalocyanine-cyclodextrin: preparation, characterization, molecular modeling, and in vitro activity†

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A novel assembling complex of hydrobobic phthalocyanine-cyclodextrin: preparation, characterization, molecular modeling, and in vitro activity

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