A Cu(I)-catalysed synthesis of substituted 3-methyleneisoindolin-1-ones using alkynyl acids as an alkyne source has been developed. The reaction involves the decarboxylative cross-coupling of 2-halobenzamides with aryl alkynyl acids, followed by 5-exo-dig heteroannulation. While reactions of 2-iodo benzamides proceeded without a ligand, for 2-bromo substrates, the assistance of a ligand is essential.
A. Gogoi, S. Guin, S. K. Rout, G. Majji and B. K. Patel, RSC Adv., 2014, 4, 59902 DOI: 10.1039/C4RA12782J
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