Highly regio- and diastereoselective construction of spirocyclopenteneoxindole phosphonates through a phosphine-catalyzed [3 + 2] annulation reaction

Abstract

A phosphine-catalyzed [3 + 2] annulation of MBH phosphonates with isatylidene malononitriles is developed. The described method, which is different from most traditional phosphorus ylide intermediate reaction modes of MBH carbonates with isatylidene malononitriles, represents a novel approach to highly regioselective and diastereoselective synthesis of spirocyclopenteneoxindole phosphonates.