Petasis and Ugi reactions are used successively without intermediate purification, effectively accomplishing a six-component reaction. The examined reactions are transferred from traditional batch reactors to an automated continuous flow microreactor setup, where optimization and kinetic analyses are performed, proposed mechanisms evaluated, and rate-limiting steps determined.
N. Heublein, J. S. Moore, C. D. Smith and K. F. Jensen, RSC Adv., 2014, 4, 63627 DOI: 10.1039/C4RA13626H
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