Issue 5, 2014

Total synthesis of propolisbenzofuran B

Abstract

The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone–ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.

Graphical abstract: Total synthesis of propolisbenzofuran B

Supplementary files

Article information

Article type
Edge Article
Submitted
01 Feb 2014
Accepted
26 Feb 2014
First published
14 Mar 2014

Chem. Sci., 2014,5, 1794-1798

Author version available

Total synthesis of propolisbenzofuran B

B. T. Jones, C. T. Avetta and R. J. Thomson, Chem. Sci., 2014, 5, 1794 DOI: 10.1039/C4SC00356J

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