Issue 11, 2014

Enhanced bone regeneration with a gold nanoparticle–hydrogel complex

Abstract

Gold nanoparticles (GNPs) are widely used in diagnostics, drug delivery, biomedical imaging, and photo-thermal therapy due to their surface plasmon resonance, fluorescence, and easy-surface functionalization. According to recent studies, GNPs display a positive effect on the osteogenic differentiation of mesenchymal stem cells (MSCs) and MC3T3-E1 osteoblast-like cells. The aim of this study was to develop a new approach for bone tissue regeneration based on the utilization of a biodegradable hydrogel loaded with GNPs. We have used photo-curable gelatin hydrogels (Gel) in order to provide a proof of principle of GNPs in regeneration strategies for bone tissue repair. We have investigated the effects of these Gel–GNP composite hydrogels both in vitro and in vivo. The in vitro results showed that the hydrogels loaded with GNPs promote proliferation, differentiation, and alkaline phosphate (ALP) activities of human adipose-derived stem cells (ADSCs) as they differentiate towards osteoblast cells in a dose-dependent manner. Moreover, the in vivo results showed that these hydrogels loaded with high concentrations of GNPs had a significant influence on new bone formation. Through these in vitro and vivo tests, we found that the Gel–GNP can be a useful material for bone tissue engineering.

Graphical abstract: Enhanced bone regeneration with a gold nanoparticle–hydrogel complex

Article information

Article type
Paper
Submitted
10 Sep 2013
Accepted
15 Dec 2013
First published
07 Jan 2014

J. Mater. Chem. B, 2014,2, 1584-1593

Author version available

Enhanced bone regeneration with a gold nanoparticle–hydrogel complex

D. N. Heo, W. Ko, M. S. Bae, J. B. Lee, D. Lee, W. Byun, C. H. Lee, E. Kim, B. Jung and I. K. Kwon, J. Mater. Chem. B, 2014, 2, 1584 DOI: 10.1039/C3TB21246G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements