Issue 17, 2014

Composite materials with embedded metal organic framework catalysts for nitric oxide release from bioavailable S-nitrosothiols

Abstract

Polyurethane/metal organic framework composite materials were prepared for the generation of the bioregulatory agent, nitric oxide (NO). Extruded tubing was fabricated though a 2-step compounding and extrusion method that yielded a uniform composition of the MOF catalyst in the tubing, where the MOF remained structurally robust during the extrusion process. The resulting MOF embedded polymeric tubing facilitated the generation of NO from bioavailable S-nitrosothiols. The function of the catalyst in the composite material was compared to neat catalysts. The substrate structure was found to have significant influence on the reactivity of the MOF catalyst with NO release times ranging from 1 to 16 h. The dosage of NO could be tuned based on the S-nitrosothiol employed. The ability for sustained NO release from a composite material is a promising approach for long-term biocompatibility.

Graphical abstract: Composite materials with embedded metal organic framework catalysts for nitric oxide release from bioavailable S-nitrosothiols

Article information

Article type
Paper
Submitted
17 Oct 2013
Accepted
25 Nov 2013
First published
09 Dec 2013

J. Mater. Chem. B, 2014,2, 2530-2536

Composite materials with embedded metal organic framework catalysts for nitric oxide release from bioavailable S-nitrosothiols

J. L. Harding and M. M. Reynolds, J. Mater. Chem. B, 2014, 2, 2530 DOI: 10.1039/C3TB21458C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements