Issue 6, 2014

Stimuli-responsive electrospun nanofibers from poly(N-isopropylacrylamide)-co-poly(acrylic acid) copolymer and polyurethane

Abstract

A thermo- and pH-sensitive copolymer of poly(N-isopropylacrylamide)-co-poly(acrylic acid) (P(NIPAAm-co-AAc)) with an adjusted lower critical solution temperature (LCST)(at 37 °C) in an aqueous medium and pH of 7.4 was synthesized by a radical copolymerization, and was characterized by Fourier-transform infrared (FTIR) spectroscopy and 1H nuclear magnetic resonance (1H-NMR) spectroscopy. Then, nanofibers composed of P(NIPAAm-co-AAc) and polyurethane (PU) were fabricated by the single-spinneret electrospinning technique and used as drug carriers by co-spinning with the water insoluble drug nifedipine (NIF). The thermo-responsive behavior of the nanofibers was detected by contact angle (CA) measurements. The release behavior of the NIF from nanofibers was observed by scanning electron microscopy (SEM) and demonstrated by UV-vis spectroscopy. It was found that the wettability of the P(NIPAAm-co-AAc) nanofibers could be switched, due to the incorporation of PU. The release amount of NIF from the nanofibers could be controlled effectively by adjusting the temperature or pH value of the aqueous medium and incorporating the hydrophobic PU.

Graphical abstract: Stimuli-responsive electrospun nanofibers from poly(N-isopropylacrylamide)-co-poly(acrylic acid) copolymer and polyurethane

Article information

Article type
Paper
Submitted
29 Oct 2013
Accepted
05 Nov 2013
First published
06 Nov 2013

J. Mater. Chem. B, 2014,2, 651-658

Stimuli-responsive electrospun nanofibers from poly(N-isopropylacrylamide)-co-poly(acrylic acid) copolymer and polyurethane

X. Lin, D. Tang, Z. Yu and Q. Feng, J. Mater. Chem. B, 2014, 2, 651 DOI: 10.1039/C3TB21519A

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