Issue 38, 2014

Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy

Abstract

The combined use nanotechnology and medical technologies holds great promise for the development and improvement of various theranostic media. Here, based on a facile hydrothermal method, polyethyleneimine (PEI) functionalized YbPO4:Er up-conversion porous nanospheres (UCPSs) were fabricated, which combined the capabilities of up-conversion luminescence (UCL)/X-ray computed tomography (CT) bimodal imaging and drug delivery. The resulting hydrophilic PEI functionalized YbPO4:Er UCPSs (PEI-UCPSs) showed uniform morphology and high crystallinity. Moreover, PEI-UCPSs possessed high drug loading capacity because of their large specific surface area, which was confirmed by the Brunauer–Emmett–Teller (BET) experiment. Cellular experiments indicated that the PEI-UCPSs had low cytotoxicity and confirmed the performance of the pH-mediated cancer targeting of PEI-UCPSs@DOX. Importantly, because of the ideal UCL property and high CT contrast both in vitro and in vivo, YbPO4:Er PEI-UCPSs could be used as an optical probe and a contrast agent for optical and CT imaging, forming a promising platform for simultaneous bioimaging and drug delivery.

Graphical abstract: Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy

Supplementary files

Article information

Article type
Paper
Submitted
30 May 2014
Accepted
01 Aug 2014
First published
20 Aug 2014

J. Mater. Chem. B, 2014,2, 6508-6516

Author version available

Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy

X. Zheng, L. Zhou, Y. Bu, W. Yin, Z. Hu, M. Li, Z. Gu and Y. Zhao, J. Mater. Chem. B, 2014, 2, 6508 DOI: 10.1039/C4TB00880D

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