Issue 38, 2014
From the journal:

Journal of Materials Chemistry B

A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C–Ag+–C DNA†

Modi Wang,‡a   Ka-Ho Leung,‡a   Sheng Lin,a   Daniel Shiu-Hin Chan,a   Chung-Hang Leungb  and  Dik-Lung Ma*ac  

* Corresponding authors

a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

c Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, P. R. China

Abstract

We report herein the ability of exonuclease III to cleave C–Ag+–C mismatched DNA, which was utilised for the construction of an exonuclease III-assisted, label-free, switch-on luminescent platform for Ag+ ions using a novel G-quadruplex-selective iridium(III) complex.

Graphical abstract: A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C–Ag+–C DNA

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Article information

DOI
https://doi.org/10.1039/C4TB01140F
Article type
Communication
Submitted
11 Jul 2014
Accepted
08 Aug 2014
First published
11 Aug 2014

J. Mater. Chem. B, 2014,2, 6467-6471

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A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C–Ag+–C DNA

M. Wang, K. Leung, S. Lin, D. S. Chan, C. Leung and D. Ma, J. Mater. Chem. B, 2014, 2, 6467 DOI: 10.1039/C4TB01140F

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