Issue 17, 2015
From the journal:

Analyst

Responsive hairpin DNA aptamer switch to program the strand displacement reaction for the enhanced electrochemical assay of ATP†

Li Wang,a   Li Fanga  and  Shufeng Liu*a  

* Corresponding authors

a Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, No. 53, Zhengzhou Rd., Qingdao, Shandong 266042, China
E-mail: sliu@qust.edu.cn

Abstract

A responsive hairpin DNA aptamer switch was ingeniously designed for enzyme-free, sensitive and selective electrochemical detection of ATP. It takes full advantage of the target-triggered liberation effect of the toehold region and the concomitant proximity effect with the branch-migration region to execute the toehold-mediated strand displacement reaction on the electrode surface.

Graphical abstract: Responsive hairpin DNA aptamer switch to program the strand displacement reaction for the enhanced electrochemical assay of ATP

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Article information

DOI
https://doi.org/10.1039/C5AN00725A
Article type
Communication
Submitted
15 Apr 2015
Accepted
14 Jul 2015
First published
15 Jul 2015

Analyst, 2015,140, 5877-5880

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Responsive hairpin DNA aptamer switch to program the strand displacement reaction for the enhanced electrochemical assay of ATP

L. Wang, L. Fang and S. Liu, Analyst, 2015, 140, 5877 DOI: 10.1039/C5AN00725A

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