Lipophilicity study of fifteen fluoroquinolones by reversed-phase thin-layer chromatography

Abstract

The lipophilicity of fifteen fluoroquinolones has been investigated. Reversed-phase thin layer chromatography with densitometric detection was applied to determine the R_M0 factor. The RP-TLC investigations were performed in mixtures of organic modifier–water. The partition coefficients of examined fluoroquinolones were also calculated with computational programs. All the obtained data, from experimental methods and theoretical calculations, were compared and a suitable conclusion was reached. The received results demonstrate that the RP-TLC method may be the only reliable technique for fluoroquinolones in describing their lipophilic nature as well as the activity.