A colorimetric and near-infrared fluorescent turn-on probe for in vitro and in vivo detection of thiophenols

Abstract

A colorimetric and near-infrared fluorescent probe for thiophenols was developed. This new probe features remarkably large Stokes shift, and shows a rapid, highly selective and sensitive detection process for thiophenols with obvious colorimetric and near-infrared fluorescence turn-on responses. The detection limit of this probe for thiophenols was found to be 70 nM. In addition, this probe shows great potential for in vitro and in vivo detection of thiophenols, which was exampled by the successful application of this probe for quantitative detection of thiophenol in real water samples and fluorescence imaging of thiophenol in living cells and zebrafish.