Issue 20, 2015
From the journal:

Analytical Methods

A fluorescent probe for thiols based on strong nucleophilic attack of sulfhydryl and its bioimaging†

Jianfang Li,a   Caixia Yin,*a   Fangjun Huo,*b   Jianbin Chao,b   Yongbin Zhangb  and  Lixi Niuc  

* Corresponding authors

a Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
E-mail: yincx@sxu.edu.cn
Web: http://ims.sxu.edu.cn/yjry/555.htm
Fax: +86 351 7011022
Tel: +86 351 7011022

b Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China
E-mail: huofj@sxu.edu.cn
Web: http://202.207.208.201/tbiaodan.php?id=3545

c Institute of Biotechnology, Shanxi University, Taiyuan 030006, China

Abstract

A fluorescent probe has been synthesized and characterized as a selective and sensitive sensor for thiol detection. The probe exhibits a rapid response and high sensitivity to thiols in HEPES : DMF = 1 : 1 (v/v pH = 7.0) solution. The practical utility of the probe was demonstrated by its application to the detection of thiols in living cells.

Graphical abstract: A fluorescent probe for thiols based on strong nucleophilic attack of sulfhydryl and its bioimaging

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Article information

DOI
https://doi.org/10.1039/C5AY01834J
Article type
Communication
Submitted
15 Jul 2015
Accepted
15 Aug 2015
First published
20 Aug 2015

Anal. Methods, 2015,7, 8545-8549

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A fluorescent probe for thiols based on strong nucleophilic attack of sulfhydryl and its bioimaging

J. Li, C. Yin, F. Huo, J. Chao, Y. Zhang and L. Niu, Anal. Methods, 2015, 7, 8545 DOI: 10.1039/C5AY01834J

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