Issue 2, 2015

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Graphical abstract: MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Supplementary files

Article information

Article type
Communication
Submitted
12 Aug 2014
Accepted
09 Oct 2014
First published
28 Oct 2014
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2015,3, 246-249

Author version available

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

D. Kalafatovic, M. Nobis, N. Javid, P. W. J. M. Frederix, K. I. Anderson, B. R. Saunders and R. V. Ulijn, Biomater. Sci., 2015, 3, 246 DOI: 10.1039/C4BM00297K

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