Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2–4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.
D. Daly, A. Al-Sabi, G. K. Kinsella, K. Nolan and J. O. Dolly, Chem. Commun., 2015, 51, 1066 DOI: 10.1039/C4CC05639F
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