Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions

Abstract

We report a visible-light-induced reductive decarboxylative C(sp³)–C(sp) bond coupling reaction to construct aryl, alkyl and silyl substituted alkynes at room temperature in organic solvents or neutral aqueous solutions. This chemoselective alkynylation was compatible with various functional groups and biomolecules, and did not affect the protein enzyme activity.