Issue 14, 2015

Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

Abstract

We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendrimeric contrast agents have great advantages as compared to their monomeric equivalents.

Graphical abstract: Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

Supplementary files

Article information

Article type
Communication
Submitted
24 Sep 2014
Accepted
30 Oct 2014
First published
31 Oct 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 2782-2785

Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

S. Gündüz, N. Nitta, S. Vibhute, S. Shibata, M. E. Mayer, N. K. Logothetis, I. Aoki and G. Angelovski, Chem. Commun., 2015, 51, 2782 DOI: 10.1039/C4CC07540D

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