Issue 1, 2015
From the journal:

Chemical Communications

Carbon quantum dot–NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors†

Colin Fowley,a   Anthony P. McHale,a   Bridgeen McCaughan,a   Aurore Fraix,b   Salvatore Sortino*b  and  John F. Callan*a  

* Corresponding authors

a Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK
E-mail: j.callan@ulster.ac.uk

b Laboratory of Photochemistry, Department of Drug Sciences, University of Catania, I-95125 Catania, Italy
E-mail: ssortino@unict.it

Abstract

We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

Graphical abstract: Carbon quantum dot–NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC07827F
Article type
Communication
Submitted
03 Oct 2014
Accepted
05 Nov 2014
First published
05 Nov 2014

Chem. Commun., 2015,51, 81-84

Permissions

Request permissions

Carbon quantum dot–NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

C. Fowley, A. P. McHale, B. McCaughan, A. Fraix, S. Sortino and J. F. Callan, Chem. Commun., 2015, 51, 81 DOI: 10.1039/C4CC07827F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements