Combination of fluoroalkylation and Kornblum–DeLaMare reaction: a new strategy for the construction of (Z)-β-perfluoroalkyl enaminones

Abstract

A novel strategy has been developed for the highly chemo- and stereo-selective synthesis of (Z)-β-perfluoroalkyl enaminones from readily available starting materials via a multicomponent radical reaction involving sequential fluoroalkylation and Kornblum–DeLaMare reaction. Notably, this methodology involves the concurrent cleavage of at least three chemical bonds, including two C–F bonds and one C–X (X = Br or I) bond, as well as the formation of three new bonds, including one CO bond, one CC bond and one C–N bond, in one pot.