Issue 5, 2015
From the journal:

Chemical Communications

Multiple turnovers of DNAzyme for amplified detection of ATP and reduced thiol in cell homogenates†

Yingshu Guo,a   Jia liu,b   Guangxu Yang,b   Xiaofeng Sun,b   Hong-Yuan Chena  and  Jing-Juan Xu*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
E-mail: xujj@nju.edu.cn
Fax: +86-25-83597294
Tel: +86-25-83597294

b Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

A conveniently amplified DNAzyme-based fluorescence strategy was designed for highly sensitive detection of ATP or reduced thiol based on the introduction of an ATP aptamer or a disulfide bond in the bioconjugates of magnetic nanoparticles (MNP) and polystyrene microsphere–DNAzyme complexes (PSM–DNAzyme).

Graphical abstract: Multiple turnovers of DNAzyme for amplified detection of ATP and reduced thiol in cell homogenates

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Article information

DOI
https://doi.org/10.1039/C4CC08428D
Article type
Communication
Submitted
25 Oct 2014
Accepted
19 Nov 2014
First published
20 Nov 2014

Chem. Commun., 2015,51, 862-865

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Multiple turnovers of DNAzyme for amplified detection of ATP and reduced thiol in cell homogenates

Y. Guo, J. liu, G. Yang, X. Sun, H. Chen and J. Xu, Chem. Commun., 2015, 51, 862 DOI: 10.1039/C4CC08428D

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