Issue 12, 2015
From the journal:

Chemical Communications

Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides†

Koji Yasui,a   Takanari Kato,a   Kohei Kojimaa  and  Kazuo Nagasawa*a  

* Corresponding authors

a Department of Life Science and Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo 184-8588, Japan
E-mail: knaga@cc.tuat.ac.jp
Fax: +81 42-388-7295

Abstract

Oxidative nitroalkylation of β-ketoamides and nitroalkanes, mediated by hypoiodide generated from tert-butyl hydrogen peroxide and a catalytic amount of guanidinium iodide, afforded the corresponding α-nitroalkyl-β-ketoamides in up to 97% yield.

Graphical abstract: Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides

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Article information

DOI
https://doi.org/10.1039/C4CC08581G
Article type
Communication
Submitted
30 Oct 2014
Accepted
17 Dec 2014
First published
18 Dec 2014

Chem. Commun., 2015,51, 2290-2293

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Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides

K. Yasui, T. Kato, K. Kojima and K. Nagasawa, Chem. Commun., 2015, 51, 2290 DOI: 10.1039/C4CC08581G

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