Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.
D. Shin, P. Lönn, S. F. Dowdy and Y. Tor, Chem. Commun., 2015, 51, 1662 DOI: 10.1039/C4CC08809C
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