A novel toehold activation strategy was developed based on hairpin-reconfiguration which was initiated by the interaction between the hairpin and different environmental stimuli (Hg2+ or ATP). Through variation of the concentration of environmental stimuli, it allowed the fine control of the DNA strand displacement rates almost 2 orders of magnitude.
J. Zhu, L. Wang and W. Jiang, Chem. Commun., 2015, 51, 2903 DOI: 10.1039/C4CC08816F
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