Issue 30, 2015
From the journal:

Chemical Communications

Acyclicl-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA†

Keiji Murayama,a   Hiromu Kashida*a  and  Hiroyuki Asanuma*a  

* Corresponding authors

a Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
E-mail: kashida@nubio.nagoya-u.ac.jp, asanuma@nubio.nagoya-u.ac.jp

Abstract

We report the hybridization properties of a novel artificial nucleic acid: acyclicL-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.

Graphical abstract: Acyclic l-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

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Article information

DOI
https://doi.org/10.1039/C4CC09244A
Article type
Communication
Submitted
19 Nov 2014
Accepted
05 Jan 2015
First published
30 Jan 2015

Chem. Commun., 2015,51, 6500-6503

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Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

K. Murayama, H. Kashida and H. Asanuma, Chem. Commun., 2015, 51, 6500 DOI: 10.1039/C4CC09244A

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