Issue 12, 2015
From the journal:

Chemical Communications

A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging†

Avik R. Sarkar,‡a   Cheol Ho Heo,‡a   Eunjin Kim,b   Hyo Won Lee,a   Hardev Singh,a   Jeong Jin Kim,a   Hyuk Kang,a   Chulhun Kang*b  and  Hwan Myung Kim*a  

* Corresponding authors

a Department of Chemistry and Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea
E-mail: kimhm@ajou.ac.kr
Fax: +82-31-219-1615

b East–West Medical Science, Kyung Hee University, Yongin 446-701, Korea
E-mail: kangch@khu.ac.kr

Abstract

We report a two-photon fluorescent probe for ratiometric imaging of cysteamine in situ. This probe can detect the levels of endogenous cysteamine with statistical significance in live cells and brain hippocampal tissues, revealing that cysteamine is localized mainly in the perikaria of the pyramidal neurons and the granule cells.

Graphical abstract: A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging

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Article information

DOI
https://doi.org/10.1039/C4CC09416F
Article type
Communication
Submitted
25 Nov 2014
Accepted
17 Dec 2014
First published
22 Dec 2014

Chem. Commun., 2015,51, 2407-2410

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A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging

A. R. Sarkar, C. H. Heo, E. Kim, H. W. Lee, H. Singh, J. J. Kim, H. Kang, C. Kang and H. M. Kim, Chem. Commun., 2015, 51, 2407 DOI: 10.1039/C4CC09416F

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