Issue 32, 2015

A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate

Abstract

We describe artificial DNA molecules exclusively consisting of four types of alkynyl C-nucleotides with nonnatural bases. The artificial DNA exhibited almost the same characteristics as natural DNA, such as in regard to the stepwise duplex and triplex formation and the right-handed higher-order structure with an antiparallel alignment fashion.

Graphical abstract: A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2014
Accepted
12 Mar 2015
First published
12 Mar 2015

Chem. Commun., 2015,51, 7043-7046

A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate

W. Shirato, J. Chiba and M. Inouye, Chem. Commun., 2015, 51, 7043 DOI: 10.1039/C4CC09486G

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