Issue 16, 2015
From the journal:

Chemical Communications

Modification of 1,2,4,5-tetrazine with cationic rhenium(i) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics†

Alex Wing-Tat Choi,a   Karson Ka-Shun Tso,a   Vicki Man-Wai Yim,a   Hua-Wei Liua  and  Kenneth Kam-Wing Lo*a  

* Corresponding authors

a Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China
E-mail: bhkenlo@cityu.edu.hk
Fax: +852 3442 0522

Abstract

New phosphorogenic bioorthogonal probes derived from mononuclear and binuclear rhenium(I) polypyridine complexes containing a 1,2,4,5-tetrazine moiety were designed; these complexes displayed substantial dienophile-induced emission enhancement, and accelerated reaction kinetics and could target a protein conjugate in living cells.

Graphical abstract: Modification of 1,2,4,5-tetrazine with cationic rhenium(i) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics

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Article information

DOI
https://doi.org/10.1039/C4CC09532D
Article type
Communication
Submitted
29 Nov 2014
Accepted
18 Jan 2015
First published
21 Jan 2015

Chem. Commun., 2015,51, 3442-3445

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Modification of 1,2,4,5-tetrazine with cationic rhenium(I) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics

A. W. Choi, K. K. Tso, V. M. Yim, H. Liu and K. K. Lo, Chem. Commun., 2015, 51, 3442 DOI: 10.1039/C4CC09532D

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