Issue 17, 2015
From the journal:

Chemical Communications

Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery†

P. Garg,‡a   S. Pandey,‡a   Hoon Seonwoo,a   Seungmin Yeom,a   Yun-Hoon Choung,b   Chong-Su Cho,c   Pill-Hoon Choung*d  and  Jong Hoon Chung*ae  

* Corresponding authors

a Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, Republic of Korea
E-mail: jchung@snu.ac.kr

b Department of Otolaryngology, Ajou University School of Medicine, Suwon 443-749, Republic of Korea

c Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea

d Department of Oral and Maxillofacial Surgery and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-774, Republic of Korea
E-mail: choungph@snu.ac.kr

e Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

Abstract

Here, we introduce a polydixylitol based highly osmotic polymer that not only transmigrates the BBB by intra-arterial infusion of osmotic polyol but also triggers cellular uptake via modulation of caveolae mediated endocytosis.

Graphical abstract: Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

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Article information

DOI
https://doi.org/10.1039/C4CC09871D
Article type
Communication
Submitted
11 Dec 2014
Accepted
14 Jan 2015
First published
15 Jan 2015

Chem. Commun., 2015,51, 3645-3648

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Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

P. Garg, S. Pandey, H. Seonwoo, S. Yeom, Y. Choung, C. Cho, P. Choung and J. Hoon Chung, Chem. Commun., 2015, 51, 3645 DOI: 10.1039/C4CC09871D

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