Issue 15, 2015
From the journal:

Chemical Communications

Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles†

Julian Wippich,a   Ingo Schnapperellea  and  Thorsten Bach*a  

* Corresponding authors

a Department Chemie and Catalysis Research Center (CRC), Technische Universität München, 85747 Garching, Germany
E-mail: thorsten.bach@ch.tum.de
Fax: +49 89 28913315
Tel: +49 89 28913330

Abstract

A total of 19 alkylated heterocycles (thiophenes, benzothiophenes, pyrroles, furans) were prepared (36–99% yield) from the respective pyridin-2-yl-substituted precursors employing alkylboronic acids as the C–H alkylating reagents in an oxidative (Ag2CO3 and 2,6-dimethyl-1,4-benzoquinone as oxidants) Pd-catalysed coupling reaction.

Graphical abstract: Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles

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Article information

DOI
https://doi.org/10.1039/C4CC10144H
Article type
Communication
Submitted
19 Dec 2014
Accepted
14 Jan 2015
First published
15 Jan 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 3166-3168

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Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles

J. Wippich, I. Schnapperelle and T. Bach, Chem. Commun., 2015, 51, 3166 DOI: 10.1039/C4CC10144H

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