Enzyme transformation to modulate the ligand–receptor interactions between small molecules

Abstract

Enzymatic transformation is a fundamental process to control ligand–receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand–receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand–receptor binding from 1 : 1 to 1 : 2. We also show that this unique integration of enzymatic transformation and ligand–receptor interactions of small molecules is able to affect the fate of cells.