Issue 21, 2015
From the journal:

Chemical Communications

Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases†

Siyu Chen,a   Yong Li,a   Yufang Hu,a   Yitao Han,a   Yan Huang,a   Zhou Nie*a  and  Shouzhuo Yaoa  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: niezhou.hnu@gmail.com
Fax: +86-731-88821848
Tel: +86-731-88821626

Abstract

A novel and label-free fluorescence assay for histone acetyltransferase (HAT) activity was established via in situ generation of a nucleic acid-mimicking CoA–Au(I) coordination polymer (CP). Moreover, the potency of this assay for HAT-targeted drug discovery was proved by screening HAT inhibitors.

Graphical abstract: Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases

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Article information

DOI
https://doi.org/10.1039/C5CC00067J
Article type
Communication
Submitted
05 Jan 2015
Accepted
03 Feb 2015
First published
03 Feb 2015

Chem. Commun., 2015,51, 4469-4472

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Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases

S. Chen, Y. Li, Y. Hu, Y. Han, Y. Huang, Z. Nie and S. Yao, Chem. Commun., 2015, 51, 4469 DOI: 10.1039/C5CC00067J

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