Issue 22, 2015
From the journal:

Chemical Communications

Visible light induced radical cyclization of o-iodophenylacrylamides: a concise synthesis of indolin-2-one†

Wuheng Dong,a   Yan Liu,b   Bei Hu,b   Kai Ren,b   Yuyuan Li,b   Xiaomin Xie,b   Yuexiu Jiang*a  and  Zhaoguo Zhang*b  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China

b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
E-mail: zhaoguo@sjtu.edu.cn

Abstract

A [Ir(ppy)2(dtb-bpy)]PF6-catalyzed intramolecular radical cyclization of o-iodophenylacrylamides affording indolin-2-ones in moderate to excellent yields via 5-exo-trig radical cyclization under visible light is presented. This method provides new access to the synthesis of indolin-2-ones under mild reaction conditions.

Graphical abstract: Visible light induced radical cyclization of o-iodophenylacrylamides: a concise synthesis of indolin-2-one

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Article information

DOI
https://doi.org/10.1039/C5CC00072F
Article type
Communication
Submitted
05 Jan 2015
Accepted
06 Feb 2015
First published
06 Feb 2015

Chem. Commun., 2015,51, 4587-4590

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Visible light induced radical cyclization of o-iodophenylacrylamides: a concise synthesis of indolin-2-one

W. Dong, Y. Liu, B. Hu, K. Ren, Y. Li, X. Xie, Y. Jiang and Z. Zhang, Chem. Commun., 2015, 51, 4587 DOI: 10.1039/C5CC00072F

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