Issue 22, 2015
From the journal:

Chemical Communications

Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and LC-MS/MS†

Dandan Li,a   You-Jun Fua  and  James F. Rusling*abc  

* Corresponding authors

a Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
E-mail: james.rusling@uconn.edu

b National University of Ireland at Galway, Ireland

c Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA

Abstract

We report here label-free metabolite–protein adduct detection and identification employing magnetic beads coated with metabolic enzymes as bioreactors to generate metabolites and possible metabolite–protein adducts for analysis by liquid chromatography-tandem mass spectrometry.

Graphical abstract: Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and LC-MS/MS

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Article information

DOI
https://doi.org/10.1039/C5CC00420A
Article type
Communication
Submitted
15 Jan 2015
Accepted
11 Feb 2015
First published
11 Feb 2015

Chem. Commun., 2015,51, 4701-4703

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Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and LC-MS/MS

D. Li, Y. Fu and J. F. Rusling, Chem. Commun., 2015, 51, 4701 DOI: 10.1039/C5CC00420A

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