Issue 21, 2015

Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

Abstract

A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.

Graphical abstract: Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2015
Accepted
05 Feb 2015
First published
06 Feb 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 4488-4491

Author version available

Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

G. L. Tolnai, A. Székely, Z. Makó, T. Gáti, J. Daru, T. Bihari, A. Stirling and Z. Novák, Chem. Commun., 2015, 51, 4488 DOI: 10.1039/C5CC00519A

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