Issue 24, 2015
From the journal:

Chemical Communications

A label-free electrochemical strategy for highly sensitive methyltransferase activity assays†

Jiawan Zhou,a   Xiaohua Zhang,a   Erhu Xiong,a   Peng Yua  and  Jinhua Chen*a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P.R. China
E-mail: chenjinhua@hnu.edu.cn
Fax: +86-731-88821961
Tel: +86-731-88821961

Abstract

A new electrochemical strategy for the simple and ultrasensitive evaluation of DNA methyltransferase (MTase) activity was developed based on electrocatalytic oxidation of ascorbic acid by graphene. In addition, the suitability of this sensing platform for MTase inhibitor screening was also demonstrated.

Graphical abstract: A label-free electrochemical strategy for highly sensitive methyltransferase activity assays

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Article information

DOI
https://doi.org/10.1039/C5CC00658A
Article type
Communication
Submitted
23 Jan 2015
Accepted
17 Feb 2015
First published
17 Feb 2015

Chem. Commun., 2015,51, 5081-5084

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A label-free electrochemical strategy for highly sensitive methyltransferase activity assays

J. Zhou, X. Zhang, E. Xiong, P. Yu and J. Chen, Chem. Commun., 2015, 51, 5081 DOI: 10.1039/C5CC00658A

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