Issue 29, 2015

Cu-catalyzed selective cascade sp3 C–H bond oxidative functionalization towards isoxazoline derivatives

Abstract

The first Cu-catalyzed cascade sp3 C–H bond oxidative functionalization of the 2-ethylazaarenes has been developed. The two different sp3 C–H bonds in 2-ethylazaarenes are selectively oxidized and four new types of bonds (C[double bond, length as m-dash]O, C[double bond, length as m-dash]N, C–C, C–O) are constructed in one operation. Starting from the simple substrates and cheap nitro source, this reaction provides an efficient approach to produce new kinds of isoxazolines.

Graphical abstract: Cu-catalyzed selective cascade sp3 C–H bond oxidative functionalization towards isoxazoline derivatives

Supplementary files

Article information

Article type
Communication
Submitted
03 Feb 2015
Accepted
04 Mar 2015
First published
04 Mar 2015

Chem. Commun., 2015,51, 6308-6311

Author version available

Cu-catalyzed selective cascade sp3 C–H bond oxidative functionalization towards isoxazoline derivatives

G. Wang, M. Cheng, R. Ma and S. Yang, Chem. Commun., 2015, 51, 6308 DOI: 10.1039/C5CC01004G

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