Sample cleanup is a major processing step in many analytical assays. Here, we propose an approach to capture-and-release of analytes based on the DNA strand displacement reaction (SDR) and demonstrate its application to a fluoroimmunoassay on beads for a thyroid cancer biomarker, thyroglobulin. The SDR-based cleanup showed no interference from matrix molecules in serum.
H. Ramezani and D. Jed Harrison, Chem. Commun., 2015, 51, 8307 DOI: 10.1039/C5CC01880C
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